Zebrafish microscopy imaging
Automated microscopy for zebrafish and other whole-organisms screening assay
ACQUIFER is your partner for zebrafish research and imaging. We have a well-established experience in microscopy imaging of zebrafish larvae and other small model-organisms, covering the full experimental workflow from sample mounting, complex imaging to image-analysis.
The ACQUIFER Imaging Machine is the ideal platform for high content screening with such animal models.
It provides highly-stable imaging conditions for time-lapse imaging of non-adherent and motion-sensitive specimen, thanks to its unique opto-mechanical design featuring moving-optics and a static stage.
Besides, the integrated environment control assures optimal in-vivo conditions for image-based screening or long-term observation of multiple developing specimen.
Our latest innovation, the photomanipulation-module streamlines the parallel conduction of laser-ablation, photo-activation or fluorescence lifetime imaging experiments.
Example Applications and Assays
High content screening in zebrafish for developmental nephrotoxicity of approved drugs. Click image to watch animation. See also: Westhoff et al (2020).
Heartbeat quantification in medaka and zebrafish embryos under physiological conditions. See also Gierten et al. (2020).
Visualizing heartbeat and blood flow in zebrafish larvae. Samples by Jana Heigwer.
Assessment of renal function in larval zebrafish. See also Steenbergen et al. (2020).
Embryonic zebrafish xenograft assay of cancer metastasis – Image courtesy of Arwin Groenewoud (Ewa Snaar-Jagalska lab, Leiden University).
Time-lapse imaging to characterize different anesthesia conditions in medaka. Click image to watch movie. See also Lischik et al. (2019).
Imaging oscillating reporter gene expression to study pattern formation in zebrafish segmentation. Image courtesy of Daniele Soroldoni and Andy Oates lab, EPFL.