Imaging machine
for High Content Screening
- Smart Image Acquisition
- Designed for experiment reproducibility
- Unique optical and mechanical design for sensitive specimen
- Data storage & processing integrated
Why IMaging Machine?
We developed our Imaging Machine for easy, precise, robust and smart high content screening applications without the need for an expert to manage the experiment. We focused on integrated data management, long term data transparency, sensitive samples and a robust machine technology that allows Imaging Machines to learn and reproduce protocols from other devices. In other words: Imaging Machines are designed for everyone to use.
Applications
Zebrafish
- Dorsal orientation tool
- Lateral orientation tool
- Image optimization – Deconvolution
- Smart Imaging interface (TCP based)
- Visualization tools
- Drosophila
- Large / thick 3D specimen
- Image optimization / de-blurring
- Smart Imaging interface (TCP based)
(Time-lapse) Cell based
- Optimized Temperature control – unique laminar flow design for MT plates
- Light power sensor at sample level
- precise re-positioning (linear motor axis + 1nm resolution encoder)
- Laser Autofocus
- Smart Imaging Interface (TCP based)
YEAST
- Static MT plate holder (for very force sensitive yeast lines)
- Laser Autofocus
- Yeast optimized image based auto-focus
- Image processing workflows
- Robotic sample preparation expertise
- Smart Imaging interface (TCP based)
Large projects
- Designed for single and multi Imaging Machine projects
- HIVE Data module integration allows seamless project scaling
- Light power, temperature, motor sensors designed for optimized data reproducibility
- Small benchtop design optimal for multi machine setups
- Smart Imaging interface (TCP based)
Robotic integration
- TCP/IP interface allows remote control from many software packages
- Robotic lid allows easy gripper access
- Sensors for position, light and temperature render hardware calibration routines obsolete
Technical details
| Mechanical design | Static sample holder, moving optics block |
| Linear Motors with absolute position encoder, 1nm resolution | |
| XY axis range | 120 mm x 80 mm, 1nm resolution, linear motor, absolute encoded |
| Z axis range | 25 mm, 1nm resolution, linear motor , absolute encoded |
| Z axis design | optimized for speed and precision (for data deconvolution) |
| Objectives | 2x, 4x, 10x, 20x, 40x (Nikon) |
| LED light source | Omicron LED-HUB , up to 6 modules parallel, temperature controlled |
| LED light wavelengths | 385, 405, 455, 470, 505, 528, 595, 625 nm |
| LED lifetime | > 15.000hours on-time |
| LED power sensor | Power Sensor at MT plate level |
| Fluo Filter blocks | custom type, up to 5 |
| Fluo Filter sets mono | any 25mm “Semrock” combination – see Semrock-Fluo-table |
| Fluo Filter sets duo-quad | in combination with LED light source module for ultra fast switching |
| Camera | Hamamatsu sCMOS 2k x 2k |
| Temperature + CO2 | |
| Incubation type | robotic lid + integrated laminar flow, pressure free |
| Incubation range | 20°C – 40°C * if T > ambient temp |
| CO2 | via external controller |
| Focussing | Laser Autofocus @780nm |
| Image based Autofocus (standard, yeast) | |
| Remote control | optional via TCP based commands from any software |
| Ambient conditions | 18°-25°C / 65° – 77 ° F (Indoor use) |
| Relative humidity 30%-80% (without condensation) | |
| Power | 120v-240V |
| Weight | 62kg |
| H x W x D | 553mm x 528mm x 555mm |
Dimensions
Your Imaging Machine Support